First Triazole-Linked Porphyrin−Fullerene Dyads

“Click-fluors”: triazole-linked saccharide sensors†

Synthesis and biological properties of triazole-linked locked nucleic acid.

We have synthesized and studied the biological and biophysical properties of triazole-linked ribo and xylo locked nucleic acid (LNA). The combination of LNA with the Isobe triazole linkage gave high binding affinity when incorporated at the 3' or 5' termini of oligonucleotides, but low binding affinity at internal positions. Antisense oligonucleotides (ASOs) and siRNAs containing triazole dimer...

Structure and dynamics of triazole-linked DNA: biocompatibility explained.

Recognition of HIV TAR RNA by triazole linked neomycin dimers.

A series of neomycin dimers have been synthesized using 'click chemistry' with varying linker functionality and length to target the TAR RNA region of HIV virus. TAR (trans activation response) RNA region, a 59 base pair stem loop structure located at 5'-end of all nascent HIV-1 transcripts interacts with a key regulatory protein, Tat, and necessitates the replication of HIV-1 virus. Neomycin, ...

Synthesis of triazole-linked morpholino oligonucleotides via Cu catalysed cycloaddition†